Was Paganini born with Ehlers-Danlos syndrome phenotype 4 or 3?

نویسنده

  • D Yücel
چکیده

bility unlikely for the following reasons: 1) Isopropanol was detected in the patient’s blood on more than one occasion during hospitalization. Specimens were drawn by different staff each time. Our current phlebotomy protocol specifically addresses the need to avoid isopropanol swab contamination. Considering the number of phiebotomists involved with the patient, it is difficult to support the contamination hypothesis. 2) Three Vacutainer Tubes received for the toxicological analyses on the patient were reasonably full. To have a blood isopropanol concentration of -400 mg/dL due to contamination, the Vacutainer Tubes would have to be contaminated with -60 L of 70% isopropanol. It is difficult to conceive how this much isopropanol could have been introduced into the specimen by contamination. 3) An experiment was conducted where blood samples from volunteers were drawn immediately after wiping their arms with isopropanol swab. When the 7or 10-mL Vacutainer Tubes were ifiled with blood and the blood was analyzed for volatiles, isopropanol was not detected. 4) Of the -30 blood specimens received daily for analysis of volatiles during the patient’s hospitalization, none showed any pattern that suggested isopropanol contamination from a venipuncture site. These observations and studies, in our opinion, make unlikely the possibility of isopropanol contamination during venipuncture of the patient.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Ehlers-Danlos syndrome: type VI A – kyphoscoliosis; a case report

Ehlers-Danlos syndrome (EDS) is a clinically heterogeneous groupof inherited disorders with ten different types, all involving agenetic defect in collagen and connective-tissue synthesis andstructure that affecting the skin, joints, and blood vessels. EDStype VIA, a very rare kyphoscoliotic type, is autosomal recessiveand clinically characterized by soft extensible skin, laxity ofjoints and kyp...

متن کامل

Ehlers-Danlos Syndrome (TYPEI) with Mental Retardation -an Unusual Association (Reports on Two Brothers)

Ehlers Danlos syndrome (EDS) is an inherited connective tissue disease due to impaired collagen metabolism. Joint hypermobility and skin hyper extensibility are the major findings. Six types of EDS are recognized. Type I or Gravis type is characterized by skin hyperextensibility, joint hypermobility, skin splitting autosoml dominancy inheritance, preterm premature rupture of membrane (PPROM) an...

متن کامل

An Iranian family with cutis laxa and classic Ehlers-Danlos syndrome

Ehlers-Danlos syndrome (EDS) is a heterogenous group of inherited disorders of connective tissue characterized by fragility of the skin and blood vessels, hyperextensibility of the skin and joint hypermobility. Cutis laxa is characteized clinically by lax, pendulous skin and histologically by loss of elastic tissue in the dermis. There are some reports of coexistence of cutis laxa with ot...

متن کامل

اهمیت شناخت سندرم Ehlers Danlos بوسیله دندانپزشکان: گزارش یک مورد

This syndrome is a genetical disorder with symptoms result from deficit in the formation of connective tissue, especially collagen fiber biosynthesis. In these patients, there is hyperelasticity and fragility of the skin and mucosa. Injuries sever bleeding, internal bleeding and hemartrosis may be seen in these patients. Wounds leave scars after healing. There is recurrent dislocation of the jo...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Clinical chemistry

دوره 41 1  شماره 

صفحات  -

تاریخ انتشار 1995